A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age

H Ahsan; J Halpern; MG Kibriya; BL Pierce; L Tong; E Gamazon; V McGuire; A Felberg; J Shi; F Jasmine; S Roy; R Brutus; M Argos; S Melkonian; J Chang-Claude; I Andrulis; JL Hopper; EM John; K Malone; G Ursin; MD Gammon; DC Thomas; D Seminara; G Casey; JA Knight; MC Southey; GG Giles; RM Santella; E Lee; D Conti; D Duggan; S Gallinger; R Haile; M Jenkins; NM Lindor; P Newcomb; K Michailidou; C Apicella; DJ Park; J Peto; O Fletcher; IDS Silva; M Lathrop; DJ Hunter; SJ Chanock; A Meindl; RK Schmutzler; B Müller-Myhsok; M Lochmann; L Beckmann; R Hein; E Makalic; DF Schmidt; QM Bui; J Stone; D Flesch-Janys; N Dahmen; H Nevanlinna; K Aittomäki; C Blomqvist; P Hall; K Czene; A Irwanto; J Liu; N Rahman; C Turnbull; AM Dunning; P Pharoah; Q Waisfisz; H Meijers-Heijboer; AG Uitterlinden; F Rivadeneira; D Nicolae; DF Easton; NJ Cox; AS Whittemore

Journal article

A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age

H Ahsan, J Halpern, MG Kibriya, BL Pierce, L Tong, E Gamazon, V McGuire, A Felberg, J Shi, F Jasmine, S Roy, R Brutus, M Argos, S Melkonian, J Chang-Claude, I Andrulis, JL Hopper, EM John, K Malone, G Ursin Show all

Cancer Epidemiology Biomarkers and Prevention | Published : 2014

DOI: 10.1158/1055-9965.EPI-13-0340

Abstract

Early-onset breast cancer (EOBC) causes substantial loss of life and productivity, creating a major burden among women worldwide. We analyzed 1,265,548 Hapmap3 single-nucleotide polymorphisms (SNP) among a discovery set of 3,523 EOBC incident cases and 2,702 population control women ages ≤ 51 years. The SNPs with smallest P values were examined in a replication set of 3,470 EOBC cases and 5,475 control women. We also tested EOBC association with 19,684 genes by annotating each gene with putative functional SNPs, and then combining their P values to obtain a gene-based P value. We examined the gene with smallest P value for replication in 1,145 breast cancer cases and 1,142 control women. The..

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University of Melbourne Researchers

Melissa Southey Author

Graham Giles Author

Mark Jenkins Author

Daniel Park Author

Related Projects (1)

NIH AUSTRALIAN BREAST CANCER FAMILY REGISTRY SOUTHEY-HOPPER

DESCRIPTION (provided by applicant): The broad objective of the Breast Cancer Family Registry (Breast CFR) is to establish and maintain a hy..

Grants

Awarded by European Commission

Funding Acknowledgements

This study was supported by NIH Grants U01CA122171, RC1CA145506, R01CA094069, and U19CA148065. The Breast Cancer Family Registry (BCFR) is supported by the NCI, NIH under RFA-CA06-503 and through cooperative agreements with members of the BCFR and principal investigators, including Cancer Care Ontario (U01 CA69467), Cancer Prevention Institute of California (CPIC; U01 CA69417), and University of Melbourne (U01 CA69638). Samples from the CPIC were processed and distributed by the Coriell Institute for Medical Research. The Colon Cancer Family Registry (CCFR) is supported by the NCI, NIH under RFA-CA-95-011.